Botox is a neuromodulator, meaning it inhibits nerve transmission. When injected, it attaches to the muscles at the injection site and blocks the release of acetylcholine, leading to muscle weakness. This has been observed in three new patients who developed generalized weakness after receiving focal injections of botulinum toxin. The cause is likely presynaptic inhibition due to systemic spread of the toxin.
It is important to use botulinum toxin with caution in patients with neurological disorders, as they may be more likely to experience this complication. It can also occur sporadically after a therapeutic injection dose in a patient who has been receiving injections for many years without side effects. Intramuscular injections of botulinum toxin type A have been found to cause calf muscle atrophy when used to treat lower limb spasticity due to cerebral palsy. The benefits of using Botox for therapeutic and medical uses may outweigh the potential long-term consequences, according to Dr.
These complications depend on the technique, as they are usually caused by misplacement of the toxin or a different muscle reactivity. To ensure patient compliance and satisfaction, an additional injection of botulinum toxin may be performed into overactivated muscles. Asymmetrical forehead lift can occur due to frontal traction of a weakened right eye orbicularis muscle. The most common side effects reported by people taking Botox in clinical studies include muscle tension and pain.
To reduce regional extravasation, the corrugator muscle can be gripped between two fingers when injecting the glabellar area. Botulism is dose-dependent and results from the diffusion of botulinum toxin into adjacent muscles from the injected muscles. A study found that animals injected with Clostridium botulinum neurotoxin complex type A (BOTOX, Allergan, Inc.) experienced muscle weakness in surrounding muscles (not injected). To minimize this risk, it is important to understand muscle anatomy and that botulinum toxin diffuses approximately one centimeter from its injection site.
There is limited documentation of facial muscle atrophy induced by botulinum toxin, despite its widespread use for reducing facial rhythm. Walter Herzog's laboratory found that botulinum toxin A easily crosses the muscle membrane barrier. If you are hesitant about traditional Botox, you can opt for a more natural alternative. However, patients who start Botox too early (in their 20s) may be at risk of suffering from this side effect.